Stem Cell Therapy for Diabetes in India

Suffering from Diabetes for a long time and looking for a natural solution? Stem Cells for Diabetes in India can help you.

Stem Cell Physician on Stem Cell Therapy for Diabetes in India

We are working with the elite stem cell technologists who brings to you this treatment at affordable costs in India. Currently, we are offering stem cell treatment in three cities in India: Chandigarh, New Delhi, and Ahmedabad.

Cost of Stem Cells for Diabetes in India

You may be wondering about the cost of stem cells for Diabetes in India. The costs start at $ 4,680 only. However, the cost is case dependent and is affected by the severity of disease and related comorbidities.

Please contact our case managers for customized treatment costs.

What are Stem Cells?

Stem cells are specialized cells of the body that have the ability to differentiate in any cell type. These are present in both embryonic and adult stages, however, we use only adult stem cells for the treatment of various diseases.

The following features make stem cells fit for therapeutic use.

• Can divide and renew for a longer duration of time.
• Act as an internal repair system of the body by replenishing the lost cells.^[2]Journal of Stem Cell Research & Therapy Stem cells: past, present, and future “…. Stem cells also act as internal repair systems of the body. …” View in Article

Adult Mesenchymal Cells

Adult mesenchymal cells (AMSC)are the best option for clinical purposes. There are many reasons for this:

• These can be differentiated in any cell type after receiving a stimulus.
• AMSC can be easily expanded under laboratory conditions (in vitro) to create the required dosage.^[3]Journal of Kidney International Supplements Biology of stem cells: an overview “….MSCs are attractive for clinical therapy because of their easy in vitro expansion and their ability to differentiate into a variety of tissues, provision of trophic support, and modulation of immune responses…” View in Article
• Unlike embryonic stem cells, no ethical concern is related to treatment with AMSC.

Can a patient’s body reject adult mesenchymal cell treatment?

No, there is no chance of immunological rejection with adult stem cell treatment. This is because our doctors use the patient’s own cells. These are called autologous adult mesenchymal stem cells.

These cells do not create an immune response after re-injection, as they lack any immunological marker which otherwise initiates a rejection response.^[4]Journal of Kidney International Supplements Biology of stem cells: an overview “….The three major problems with ESCs—ethical issues, immunological rejection problems, and the potential of developing teratomas—are avoided with the use of adult stem cells…” View in Article

Read more about Stem Cell Treatment in India here.

What is Diabetes?

Diabetes is a group of disease that increases blood glucose levels to an extent where the body cannot metabolize it further. Due to this, the patient may experience many problems like cardiomyopathy, neuropathy, weight loss or weight gain, visionary problems, etc.

Types of Diabetes

There are two major types of diabetes which are commonly found all over the world. These are discussed in detail below:

Type-1 Diabetes

During this chronic condition, the pancreas either produces negligible insulin or does not produce it at all. ^[5]Mayo Clinic Type 1 diabetes “….Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin…” View in Article This causes glucose build-up in the blood which is harmful to the body.

• Synonyms: Juvenile diabetes or insulin-dependent diabetes.
• Contributing Factors: genetics, exposure to viruses, and another environmental factor. However, the exact reason is unknown.
• Patient’s demographic: Adolescents and childhood
• Symptoms: Thirst, frequent urination, hyperglycemia, insulin dependency, etc
• Possible Treatment: Insulin injections/tablets, life-style management, islet cell transplant, immune therapies, etc.

Check out this video to understand how stem cells treat type-1 diabetes.

Type-2 Diabetes

Type-2 Diabetes is characterized by persistent hyperglycemia. This may be due to less insulin secretion or insulin resistance developed in the body.

• Synonyms: Adult-onset diabetes and Type-2 Diabetes Mellitus.
• Contributing Factors: Genetics, family history, obesity, insulin resistance, etc^[7]National Institute of Diabetes and Digestive and Kidney Diseases Symptoms & Causes of Diabetes “….Type 2 diabetes—the most common form of diabetes—is caused by several factors, including lifestyle factors and genes…” View in Article.
• Patient’s demographic: 45 years or old. Common in African American, Hispanic/Latino, American Indian, Asian American, or Pacific Islander.^[8]National Institute of Diabetes and Digestive and Kidney Diseases Type 2 Diabetes “….You can develop type 2 diabetes at any age, even during childhood. However, type 2 diabetes occurs most often in middle-aged and older people…” View in Article
• Symptoms: Hungry and lethargic, blurry vision, heart disease, frequent thirst, and urination, insulin insensitivity, etc.
• Possible Treatment: Medications, lifestyle changes like quitting smoking, exercise, stem cell therapy for type-2 diabetes.

What Happens When Diabetes is Left Untreated?

Diabetes causes increased blood sugar levels which affect the normal functioning of all the body organs. If diabetes is left untreated, the patient may suffer from severe instances like:

• Nerve damage (neuropathy)
• Kidney damage (nephropathy) leading to dialysis
• Cardiac failure
• Stroke
• Undetected large vessel atherosclerotic disease ^[9]Journal of Diabetes Care Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions “….Untreated type 2 diabetes may contribute to subclinical microvascular disease and undetected large vessel atherosclerotic disease…” View in Article

Why Stem Cells for Diabetes?

Stem Cells are pluripotent and totipotent in nature. This property helps them in rejuvenating and replacing the faulty cells of the body.

Dr. Anand Srivastava on Stem Cell Treatment for Diabetes

Diabetes, on the other hand, is an end product of faulty pancreatic islet beta cells. Adult mesenchymal stem cells help the following organs that are affected by diabetes:

Pancreas:

• Promotes the regeneration of pancreatic islet beta cells.
• Protects endogenous pancreatic islet beta cells from programmed cells death.
• Eliminates insulin resistance of peripheral tissues^[10]Journal of Diabetology & Metabolic Syndrome Mesenchymal stem cell therapy in type 2 diabetes mellitus “…. MSCs are known to promote the regeneration of pancreatic islet beta cells, protect…microenvironment driven by the secretion of paracrine factors or the deposition of the extracellular matrix …” View in Article.

Heart:

• Improves overall blood circulation in the heart.
• Stimulates the synthesis of new heart muscles (Myogenesis) and new blood vessels (Angiogenesis)^[11]Stem Cells Journal Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus “Improvement in cardiac function…MSC-derived paracrine factors capable of cardioprotection…” View in Article.

Muscles Cells

• Mesenchymal stem cells stimulate certain growth factors (VEGF and bFGF).
• This promotes new blood vessel formation(neovascularization).

Nerve Cells

• The growth factors stimulated by stem cells also promote neural cell regeneration.
• The process improves diabetic polyneuropathy and slows down the aging process.

Partner Hospital

Medical Tourism Corporation has partnered with the Global Institute Of Stem Cell Therapy and Research (GIOSTAR). It is headquartered in San Diego, California (U.S.A.), and has branches spread out in Mexico and India.

Key Features:

• Experienced doctors
• Proven results
• Multiple branches in India and abroad
• In-house physiotherapy center
• Ambulance service
• Fully furnished patient and attendant room

Good News!

Our partner hospital has filed for Pre-IND with the FDA and will soon be initiating their IND filing. We can expect a stem cell clinical trial for Type-2 diabetes patients soon.

Procedure for Stem Cell Treatment

After patient history and eligibility is checked, the stem cell procedure begins

Session 1: Liposuction and Priming Dose

After you have received approval for stem cell therapy, your doctor will extract stem cells from your lower abdomen. You will also receive a priming dose on Day 1 of the procedure.

The priming dose is unstimulated cells that trigger your metabolism. This will also condition your body for the actual treatment.

Dose Calculation and Preparation

Your dose is calculated, created, and stored till the last day of your procedure.  It usually takes 2-3 weeks to prepare your dosage.

Session 2: Intravenous Injections

During your second session, you will receive an intravenous injection of stem cells. IV injections have better reach in diabetes patients.

Session 3: Final Dose

Usually, the stem cell treatment for diabetes procedure comprises of 3 sessions. However, if your doctor feels that an additional session would be helpful, then they will suggest another session.

Stay Duration

Since intravenous injections are easy to monitor, your ideal stay for diabetes treatment at Giostar is a short trip of 7 days*.

*Please note, quarantine time for outdoor patients is not included.

Precautions with Stem Cell Treatment

Stem cells do not have side effects as these are natural cells of your own body. However, you must take care of the following for better results:

• Avoid flights for 24-48 hours after treatment as it may cause severe headaches
• Refer a dietitian for nutrition support
• Maintain a healthy lifestyle

Patient Review

Mr. Kirit, a high diabetic patient received stem cells from Giostar India. After 6 months, his comorbidities decreased along with the blood sugar levels. Check out what he and his doctor have to say about his journey with us.

Happy Patient Review

References:

1. WHO: Diabetes
2. Journal of Stem Cell Research & Therapy: Stem Cells: Past, Present, and Future
3. Kidney International Supplements: Biology of Stem Cells: An Overview
4. Mayo Clinic: Type-1 Diabetes
5. Oman Medical Journal: Type 2 Diabetes Mellitus: A Review of Current Trends
6. National Institute of Diabetes and Digestive and Kidney Diseases: Symptoms & Causes of Diabetes
7. National Institute of Diabetes and Digestive and Kidney Diseases: Type-2 Diabetes
8. Journal of Diabetes Care: Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions
9. Journal of Stem Cells Research Development & Therapy: Therapeutic Application Of Autologous ADMSCS (Adipose Derived Mesenchymal Stem Cells) And Islet Like Cell Aggregates (ICAS) Derived From Them In Type 1 And 2 Diabetes Mellitus – A Proof Of Concept Study
10. Journal of Diabetology & Metabolic Syndrome: Mesenchymal Stem Cell Therapy in Type 2 Diabetes Mellitus
11. Journal of Stem Cell Research, Development and Therapy: Therapeutic Application Of Autologous ADMSCS (Adipose Derived Mesenchymal Stem Cells) And Islet Like Cell Aggregates (ICAS) Derived From Them In Type 1 And 2 Diabetes Mellitus – A Proof Of Concept Study
12. Stem Cells Journal: Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus